Endocrine Abstracts

Annexin 1 (ANXA1) is a member of the annexin family of phospholipid- and calcium- binding proteins with a well-demonstrated role in the inhibitory actions of glucocorticoids on the release of ACTH, TSH, GH and PRL from the anterior pituitary. ANXA1 and ANXA1 truncated peptides have also recently been found to mimic glucocorticoid suppression of LH release (John et al, 2003 J Neuroendocrinol 15, 946-57). Here we test the hypothesis that because ANXA1 mediates some of the inhibi...